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Differential confounding of rare and common variants in spatially structured populations

Well-powered genome-wide association studies, now possible through advances in technology and large-scale collaborative projects, promise to reveal the contribution of rare variants to complex traits and disease. However, while population structure is a known confounder of association studies, it is...

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Detalhes bibliográficos
Main Authors: Mathieson, Iain, McVean, Gil
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303124/
https://ncbi.nlm.nih.gov/pubmed/22306651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1074
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