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Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent, i.e., targeting common pathological conditions arising from many disease-causing mut...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Lobanova, Ekaterina S., Finkelstein, Stella, Li, Jing, Travis, Amanda M., Hao, Ying, Klingeborn, Mikael, Skiba, Nikolai P., Deshaies, Raymond J., Arshavsky, Vadim Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928105/
https://ncbi.nlm.nih.gov/pubmed/29712894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04117-8
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