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Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration
Inherited retinal degenerations, caused by mutations in over 100 individual genes, affect approximately 2 million people worldwide. Many of the underlying mutations cause protein misfolding or mistargeting in affected photoreceptors. This places an increased burden on the protein folding and degrada...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683722/ https://ncbi.nlm.nih.gov/pubmed/23716657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305521110 |
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