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Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction
DNA polymerases catalyze efficient and high fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse reaction, pyrophosphorolysis, removing the DNA primer terminus and generating deoxynucleoside triphosphates. Since pyrophosphorolysis can influ...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605435/ https://ncbi.nlm.nih.gov/pubmed/28759020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2450 |
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