Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

DNA polymerases catalyze efficient and high fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse reaction, pyrophosphorolysis, removing the DNA primer terminus and generating deoxynucleoside triphosphates. Since pyrophosphorolysis can influ...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Shock, David D., Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605435/
https://ncbi.nlm.nih.gov/pubmed/28759020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2450
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