DNA Polymerase β Substrate Specificity: SIDE CHAIN MODULATION OF THE “A-RULE”

Apurinic/apyrimidinic (AP) sites are continuously generated in genomic DNA. Left unrepaired, AP sites represent noninstructional premutagenic lesions that are impediments to DNA synthesis. When DNA polymerases encounter an AP site, they generally insert dAMP. This preferential insertion is referred...

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Detalhes bibliográficos
Main Authors: Beard, William A., Shock, David D., Batra, Vinod K., Pedersen, Lars C., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797239/
https://ncbi.nlm.nih.gov/pubmed/19759017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029843
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