DNA Polymerase β Substrate Specificity: SIDE CHAIN MODULATION OF THE “A-RULE”

Apurinic/apyrimidinic (AP) sites are continuously generated in genomic DNA. Left unrepaired, AP sites represent noninstructional premutagenic lesions that are impediments to DNA synthesis. When DNA polymerases encounter an AP site, they generally insert dAMP. This preferential insertion is referred...

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Bibliographische Detailangaben
Hauptverfasser: Beard, William A., Shock, David D., Batra, Vinod K., Pedersen, Lars C., Wilson, Samuel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797239/
https://ncbi.nlm.nih.gov/pubmed/19759017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029843
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