Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

The oxidized DNA base 8-oxoguanine (8-oxoG) is implicated in neuronal CAG repeat expansion associated with Huntington disease, yet it is unclear how such a DNA base lesion and its repair might cause the expansion. Here, we discovered size-limited expansion of CAG repeats during repair of 8-oxoG in a...

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Bibliografiset tiedot
Päätekijät: Liu, Yuan, Prasad, Rajendra, Beard, William A., Hou, Esther W., Horton, Julie K., McMurray, Cynthia T., Wilson, Samuel H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788885/
https://ncbi.nlm.nih.gov/pubmed/19674974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050286
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