Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

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Bibliografske podrobnosti
Main Authors: Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
DNA Dynamics and Chromosome Structure
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC207578/
https://ncbi.nlm.nih.gov/pubmed/14560028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7849-7860.2003
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