Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

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Bibliographische Detailangaben
Hauptverfasser: Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC207578/
https://ncbi.nlm.nih.gov/pubmed/14560028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7849-7860.2003
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