Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7849-7860.2003
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!