Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2003
Gaiak:
DNA Dynamics and Chromosome Structure
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC207578/
https://ncbi.nlm.nih.gov/pubmed/14560028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7849-7860.2003
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak