Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

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Detalles Bibliográficos
Autores principales: Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
DNA Dynamics and Chromosome Structure
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC207578/
https://ncbi.nlm.nih.gov/pubmed/14560028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7849-7860.2003
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