Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2003
Matèries:	DNA Dynamics and Chromosome Structure
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7849-7860.2003
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