Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat Fragility

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Callahan, Julie L., Andrews, Kenneth J., Zakian, Virginia A., Freudenreich, Catherine H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207578/
https://ncbi.nlm.nih.gov/pubmed/14560028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7849-7860.2003
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados