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Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity

Huntington's Disease is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. Whether somatic expansion contributed to toxicity was unknown. From extensive work from multiple laboratories, it has been mad...

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Bibliografski detalji
Izdano u:Rare Dis
Glavni autori: Budworth, Helen, McMurray, Cynthia T.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838321/
https://ncbi.nlm.nih.gov/pubmed/27141411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21675511.2015.1131885
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