DNA Polymerase β Substrate Specificity: SIDE CHAIN MODULATION OF THE “A-RULE”

Apurinic/apyrimidinic (AP) sites are continuously generated in genomic DNA. Left unrepaired, AP sites represent noninstructional premutagenic lesions that are impediments to DNA synthesis. When DNA polymerases encounter an AP site, they generally insert dAMP. This preferential insertion is referred...

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Détails bibliographiques
Auteurs principaux: Beard, William A., Shock, David D., Batra, Vinod K., Pedersen, Lars C., Wilson, Samuel H.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797239/
https://ncbi.nlm.nih.gov/pubmed/19759017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029843
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