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DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

DNA polymerase β has two DNA-binding domains that interact with the opposite sides of short DNA gaps. These domains contribute two activities that modify the 5′ and 3′ margins of gapped DNA during base excision repair. DNA gaps greater than 1 nucleotide (nt) pose an architectural and logistical prob...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Howard, Michael J., Cavanaugh, Nisha A., Batra, Vinod K., Shock, David D., Beard, William A., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956524/
https://ncbi.nlm.nih.gov/pubmed/31801827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010594
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