DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

DNA polymerase β has two DNA-binding domains that interact with the opposite sides of short DNA gaps. These domains contribute two activities that modify the 5′ and 3′ margins of gapped DNA during base excision repair. DNA gaps greater than 1 nucleotide (nt) pose an architectural and logistical prob...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Howard, Michael J., Cavanaugh, Nisha A., Batra, Vinod K., Shock, David D., Beard, William A., Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956524/
https://ncbi.nlm.nih.gov/pubmed/31801827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010594
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