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Structural Analysis of Mispaired DNA Termini Transitioning to DNA Polymerase Pre-catalytic Complexes Supports an Induced Fit Fidelity Mechanism
High fidelity DNA synthesis requires that polymerases display a strong preference for right nucleotide insertion. When the wrong nucleotide is inserted, the polymerase deters extension from the mismatched DNA terminus. Twenty-three crystallographic structures of DNA polymerase β with terminal templa...
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| Publicado en: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5093059/ https://ncbi.nlm.nih.gov/pubmed/27642161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.006 |
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