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Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β
Based on a recent ternary complex crystal structure of human DNA polymerase β with a G:A mismatch in the active site, we carried out a theoretical investigation of the catalytic mechanism of incorrect nucleotide incorporation using molecular dynamics simulation, quantum mechanics, combined quantum m...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2311328/ https://ncbi.nlm.nih.gov/pubmed/18391201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801257105 |
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