Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

Based on a recent ternary complex crystal structure of human DNA polymerase β with a G:A mismatch in the active site, we carried out a theoretical investigation of the catalytic mechanism of incorrect nucleotide incorporation using molecular dynamics simulation, quantum mechanics, combined quantum m...

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Bibliografiska uppgifter
Huvudupphovsmän: Lin, Ping, Batra, Vinod K., Pedersen, Lars C., Beard, William A., Wilson, Samuel H., Pedersen, Lee G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311328/
https://ncbi.nlm.nih.gov/pubmed/18391201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801257105
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