Structural Analysis of Mispaired DNA Termini Transitioning to DNA Polymerase Pre-catalytic Complexes Supports an Induced Fit Fidelity Mechanism

High fidelity DNA synthesis requires that polymerases display a strong preference for right nucleotide insertion. When the wrong nucleotide is inserted, the polymerase deters extension from the mismatched DNA terminus. Twenty-three crystallographic structures of DNA polymerase β with terminal templa...

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Bibliographic Details
Published in:Structure
Main Authors: Batra, Vinod K., Beard, William A., Pedersen, Lars C., Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093059/
https://ncbi.nlm.nih.gov/pubmed/27642161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.006
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