Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associ...

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Pubblicato in:Nat Genet
Autori principali: Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449296/
https://ncbi.nlm.nih.gov/pubmed/25894500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3268
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