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1

JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

Por Kostecka, A, Sznarkowska, A, Meller, K, Acedo, P, Shi, Y, Mohammad Sakil, H A, Kawiak, A, Lion, M, Królicka, A, Wilhelm, M, Inga, A, Zawacka-Pankau, J
Publicado no Cell Death Dis (2014)

“... current anti-cancer therapies. Additionally, in ROS-compromised cancer cells ubiquitin proteasome system...”
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2

Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann

Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann

Publicado em 2014

Assuntos: “...A Model For Life...”
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3

Systems biology of cisplatin resistance: past, present and future

Systems biology of cisplatin resistance: past, present and future

Por Galluzzi, L, Vitale, I, Michels, J, Brenner, C, Szabadkai, G, Harel-Bellan, A, Castedo, M, Kroemer, G
Publicado em 2014

“..., bladder and lung cancers. For a long time, the antineoplastic effects of cisplatin have been fully...”
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4

A model 450 million years in the making: zebrafish and vertebrate immunity

A model 450 million years in the making: zebrafish and vertebrate immunity

Por Renshaw, Stephen A., Trede, Nikolaus S.
Publicado em 2012

“...Since its first splash 30 years ago, the use of the zebrafish model has been extended from a tool...”
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5

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain...

Por Schultz, Laura E., Haltom, Jeffrey A., Almeida, Maira P., Wierson, Wesley A., Solin, Staci L., Weiss, Trevor J., Helmer, Jordan A., Sandquist, Elizabeth J., Shive, Heather R., McGrail, Maura
Publicado no Dis Model Mech (2018)

“... regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant...”
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6

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Por Johnstone, Cameron N., Pattison, Andrew D., Gorringe, Kylie L., Harrison, Paul F., Powell, David R., Lock, Peter, Baloyan, David, Ernst, Matthias, Stewart, Alastair G., Beilharz, Traude H., Anderson, Robin L.
Publicado no Dis Model Mech (2018)

“... the molecular players that drive the various hallmarks of cancer. To determine the molecular regulators...”
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7

Benign lymphoepithelial cyst of parotid gland: Review and case report

Benign lymphoepithelial cyst of parotid gland: Review and case report

Por Joshi, Jaya, Shah, Sonalee, Agarwal, Deepak, Khasgiwal, Ankit
Publicado no J Oral Maxillofac Pathol (2018)

“... be located in the salivary glands, mostly in the parotids. A 35-year-old male reported to Government Dental...”
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8

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

Por Scott, Milcah C., Tomiyasu, Hirotaka, Garbe, John R., Cornax, Ingrid, Amaya, Clarissa, O'Sullivan, M. Gerard, Subramanian, Subbaya, Bryan, Brad A., Modiano, Jaime F.
Publicado no Dis Model Mech (2016)

“... in mouse models. This system provides a resource to understand essential interactions between tumor cells...”
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9

Cell cycle inhibition as a strategy for treatment of central nervous system diseases which must not block normal neurogenesis

Cell cycle inhibition as a strategy for treatment of central nervous system diseases which must not block normal neurogenesis

Por Liu, Da-Zhi, Ander, Bradley P., Sharp, Frank R.
Publicado em 2009

“... molecules that can drive a neuron into the cell cycle in various CNS diseases. We also discuss...”
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10

Models of ovarian cancer metastasis: Murine models

Models of ovarian cancer metastasis: Murine models

Por Šale, Sanja, Orsulic, Sandra
Publicado em 2006

“... provided a valuable system for pre-clinical trials, however, the genetic complexity of human tumors has...”
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11

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

Por Callahan, Scott J., Tepan, Stephanie, Zhang, Yan M., Lindsay, Helen, Burger, Alexa, Campbell, Nathaniel R., Kim, Isabella S., Hollmann, Travis J., Studer, Lorenz, Mosimann, Christian, White, Richard M.
Publicado no Dis Model Mech (2018)

“... modeling of somatic gene alterations and cancer progression at a scale not achievable in other in vivo...”
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12

In vivo models in breast cancer research: progress, challenges and future directions

In vivo models in breast cancer research: progress, challenges and future directions

Por Holen, Ingunn, Speirs, Valerie, Morrissey, Bethny, Blyth, Karen
Publicado no Dis Model Mech (2017)

“... of breast cancer, this article provides a perspective on the many varied uses of these models in breast...”
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13

Modulation of A(1) and A(2B) adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

Modulation of A(1) and A(2B) adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

Por Daniele, S, Zappelli, E, Natali, L, Martini, C, Trincavelli, M L
Publicado no Cell Death Dis (2014)

“..., are as follows: (i) by A(2B)AR potentiating the pro-apoptotic effects of TMZ and (ii) by A(1)AR driving cells...”
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14

Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis

Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis

Por Fazio, Chiara, Ricciardiello, Luigi
Publicado no Cell Death Dis (2016)

“...The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate...”
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15

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

Por Petroni, Marialaura, Sardina, Francesca, Infante, Paola, Bartolazzi, Armando, Locatelli, Erica, Fabretti, Francesca, Di Giulio, Stefano, Capalbo, Carlo, Cardinali, Beatrice, Coppa, Anna, Tessitore, Alessandra, Colicchia, Valeria, Sahùn Roncero, Maria, Belardinilli, Francesca, Di Marcotullio, Lucia, Soddu, Silvia, Comes Franchini, Mauro, Petricci, Elena, Gulino, Alberto, Giannini, Giuseppe
Publicado no Cell Death Dis (2018)

“..., often due to genetic amplification, represents the driving oncogenic event for a number of human tumors...”
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16

Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies

Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies

Por Mattia, Gianfranco, Puglisi, Rossella, Ascione, Barbara, Malorni, Walter, Carè, Alessandra, Matarrese, Paola
Publicado no Cell Death Dis (2018)

“... in which a drug (chemical or biological) is developed with the goal of exclusively destroying cancer cells...”
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17

Insights into the role of DNA methylation in disease through the use of mouse models

Insights into the role of DNA methylation in disease through the use of mouse models

Por Conerly, Melissa, Grady, William M.
Publicado em 2010

“... that epigenetic alterations are common in cancer and probably cooperate with genetic alterations to drive cancer...”
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18

Mitochondrial DNA damage induces apoptosis in senescent cells

Mitochondrial DNA damage induces apoptosis in senescent cells

Por Laberge, R-M, Adler, D, DeMaria, M, Mechtouf, N, Teachenor, R, Cardin, G B, Desprez, P-Y, Campisi, J, Rodier, F
Publicado em 2013

“...Senescence is a cellular response to damage and stress. The senescence response prevents cancer...”
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19

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors

Por Wang, Tao, Lu, Rong, Kapur, Payal, Jaiswal, Bijay S., Hannan, Raquibul, Zhang, Ze, Pedrosa, Ivan, Luke, Jason J., Zhang, He, Goldstein, Leonard D, Yousuf, Qurratulain, Yi-Feng, Gu, McKenzie, Tiffani, Joyce, Allison, Kim, Min S, Wang, Xinlei, Luo, Danni, Onabolu, Oreoluwa, Stevens, Christina, Xie, Zhiqun, Chen, Mingyi, Filatenkov, Alexander, Torrealba, Jose, Luo, Xin, Guo, Wenbin, He, Jingxuan, Stawiski, Eric, Modrusan, Zora, Durinck, Steffen, Seshagiri, Somasekar, Brugarolas, James
Publicado no Cancer Discov (2018)

“.... These data provide a missing link between tumor cells, the TME, and systemic factors. STATEMENT...”
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20

Foxo/Atrogin induction in human and experimental myositis

Foxo/Atrogin induction in human and experimental myositis

Por Lee, Han-Kyu, Rocnik, Edward, Fu, Qinghao, Kwon, Bumsup, Zeng, Ling, Walsh, Kenneth, Querfurth, Henry
Publicado em 2012

“...Skeletal muscle atrophy can occur rapidly in various fasting, cancerous, systemic inflammatory...”
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