Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumors caused by TALEN or CRISPR targeting are histolog...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Schultz, Laura E., Haltom, Jeffrey A., Almeida, Maira P., Wierson, Wesley A., Solin, Staci L., Weiss, Trevor J., Helmer, Jordan A., Sandquist, Elizabeth J., Shive, Heather R., McGrail, Maura
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031359/
https://ncbi.nlm.nih.gov/pubmed/29914980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.034124
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