JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

Hyperproliferating cancer cells produce energy mainly from aerobic glycolysis, which results in elevated ROS levels. Thus aggressive tumors often possess enhanced anti-oxidant capacity that impedes many current anti-cancer therapies. Additionally, in ROS-compromised cancer cells ubiquitin proteasome...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Kostecka, A, Sznarkowska, A, Meller, K, Acedo, P, Shi, Y, Mohammad Sakil, H A, Kawiak, A, Lion, M, Królicka, A, Wilhelm, M, Inga, A, Zawacka-Pankau, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649515/
https://ncbi.nlm.nih.gov/pubmed/25341038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.408
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