MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of deleterious DNA double-strand breaks. In humans, hypomorphic mutations in these genes lead to DNA damage response (DDR)-defective and cancer-pron...

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Publicado no:Cell Death Dis
Main Authors: Petroni, Marialaura, Sardina, Francesca, Infante, Paola, Bartolazzi, Armando, Locatelli, Erica, Fabretti, Francesca, Di Giulio, Stefano, Capalbo, Carlo, Cardinali, Beatrice, Coppa, Anna, Tessitore, Alessandra, Colicchia, Valeria, Sahùn Roncero, Maria, Belardinilli, Francesca, Di Marcotullio, Lucia, Soddu, Silvia, Comes Franchini, Mauro, Petricci, Elena, Gulino, Alberto, Giannini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117286/
https://ncbi.nlm.nih.gov/pubmed/30166519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0924-z
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