The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathoge...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Petroni, M, Sardina, F, Heil, C, Sahún-Roncero, M, Colicchia, V, Veschi, V, Albini, S, Fruci, D, Ricci, B, Soriani, A, Di Marcotullio, L, Screpanti, I, Gulino, A, Giannini, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716299/
https://ncbi.nlm.nih.gov/pubmed/26068589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.81
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