p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Both fission yeast and mammalian cells require the function of the checkpoint kinase CHK1 for G(2) arrest after DNA damage. The tumor suppressor p53, a well-studied stress response factor, has also been shown to play a role in DNA damage G(2) arrest, although in a manner that is probably independent...

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Bibliografiske detaljer
Main Authors: Gottifredi, Vanesa, Karni-Schmidt, Orit, Shieh, Sheau-Yann, Prives, Carol
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC99561/
https://ncbi.nlm.nih.gov/pubmed/11158294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1066-1076.2001
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