hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

hMSH2⋅hMSH6 heterodimer (hMutSα) and hMLH1⋅hPMS2 complex (hMutLα) have been implicated in the cytotoxic response of mammalian cells to a number of DNA-damaging compounds, including methylating agents that produce O(6)-methylguanine (O(6)MeG) adducts. This study demonstrates that O(6)MeG lesions, in...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Duckett, Derek R., Bronstein, S. Maynard, Taya, Yoichi, Modrich, Paul
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC22926/
https://ncbi.nlm.nih.gov/pubmed/10535931
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki