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hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

hMSH2⋅hMSH6 heterodimer (hMutSα) and hMLH1⋅hPMS2 complex (hMutLα) have been implicated in the cytotoxic response of mammalian cells to a number of DNA-damaging compounds, including methylating agents that produce O(6)-methylguanine (O(6)MeG) adducts. This study demonstrates that O(6)MeG lesions, in...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Duckett, Derek R., Bronstein, S. Maynard, Taya, Yoichi, Modrich, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12384
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