hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

hMSH2⋅hMSH6 heterodimer (hMutSα) and hMLH1⋅hPMS2 complex (hMutLα) have been implicated in the cytotoxic response of mammalian cells to a number of DNA-damaging compounds, including methylating agents that produce O(6)-methylguanine (O(6)MeG) adducts. This study demonstrates that O(6)MeG lesions, in...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Duckett, Derek R., Bronstein, S. Maynard, Taya, Yoichi, Modrich, Paul
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1999
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC22926/
https://ncbi.nlm.nih.gov/pubmed/10535931
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы