Mutation detection with MutH, MutL, and MutS mismatch repair proteins.
Escherichia coli methyl-directed mismatch repair is initiated by MutS-, MutL-, and ATP-dependent activation of MutH endonuclease, which cleaves at d(GATC) sites in the vicinity of a mismatch. This reaction provides an efficient method for detection of mismatches in heteroduplexes produced by hybridi...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1996
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39545/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633074/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4374 |
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