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The role of DNA mismatch repair mutS/mutL homolog genes in spermatogenesis and male infertility: a systematic review and cohort study

Abstract Background Recent research in male infertility genetics has identified numerous candidate genes, some of which were also involved in DNA repair. Mismatch repair (MMR) genes, such as MSH4 and MSH5, have been linked to male infertility due to their role in meiosis, suggesting that other MMR g...

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Principais autores: Rebeka Podgrajsek, Alenka Hodzic, Ales Maver, Martin Stimpfel, Aleksander Andjelic, Olivera Miljanovic, Momcilo Ristanovic, Ivana Novakovic, Dijana Plaseska-Karanfilska, Predrag Noveski, Sasa Ostojic, Alena Buretic-Tomljanovic, Borut Peterlin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:Reproductive Biology and Endocrinology
Assuntos:
Male infertility
Spermatogenesis
Mismatch repair
MSH
MLH
Acesso em linha:https://doi.org/10.1186/s12958-025-01493-x
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