p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Both fission yeast and mammalian cells require the function of the checkpoint kinase CHK1 for G(2) arrest after DNA damage. The tumor suppressor p53, a well-studied stress response factor, has also been shown to play a role in DNA damage G(2) arrest, although in a manner that is probably independent...

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Detalhes bibliográficos
Main Authors: Gottifredi, Vanesa, Karni-Schmidt, Orit, Shieh, Sheau-Yann, Prives, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99561/
https://ncbi.nlm.nih.gov/pubmed/11158294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1066-1076.2001
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