Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Main Authors: Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2001
Ábhair:
Mechanisms of Action: Physiological Effects
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC90259/
https://ncbi.nlm.nih.gov/pubmed/11120964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.187-195.2001
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