Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Bibliografski detalji
Glavni autori: Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90259/
https://ncbi.nlm.nih.gov/pubmed/11120964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.187-195.2001
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