Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Bibliographische Detailangaben
Hauptverfasser: Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90259/
https://ncbi.nlm.nih.gov/pubmed/11120964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.187-195.2001
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