Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations

A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153–165,...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Nelson, Richard G., Rosowsky, Andre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Susceptibility
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3293-3303.2001
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