Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations

A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153–165,...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Nelson, Richard G., Rosowsky, Andre
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Susceptibility
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3293-3303.2001
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