Загрузка...

Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations

A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153–165,...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Nelson, Richard G., Rosowsky, Andre
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC90829/
https://ncbi.nlm.nih.gov/pubmed/11709300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3293-3303.2001
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!