Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120964/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.1.187-195.2001
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