Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Argitaratua izan da:	Antimicrob Agents Chemother
Egile Nagusiak:	Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2001
Gaiak:	Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120964/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.1.187-195.2001
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