Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Bibliografiske detaljer
Main Authors: Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90259/
https://ncbi.nlm.nih.gov/pubmed/11120964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.187-195.2001
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