Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa

Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific t...

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Autori principali: Lau, Hollis, Ferlan, Jill T., Brophy, Victoria Hertle, Rosowsky, Andre, Sibley, Carol Hopkins
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90259/
https://ncbi.nlm.nih.gov/pubmed/11120964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.187-195.2001
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