Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase

The ongoing selection of multidrug-resistant strains of Mycobacterium tuberculosis has markedly reduced the effectiveness of the standard treatment regimens. Thus, there is an urgent need for new drugs that are potent inhibitors of M. tuberculosis, that exhibit favorable resistance profiles, and tha...

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Päätekijät: Gerum, A'Lissa B., Ulmer, Jonathan E., Jacobus, David P., Jensen, Norman P., Sherman, David R., Sibley, Carol Hopkins
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2002
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC128743/
https://ncbi.nlm.nih.gov/pubmed/12384337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3362-3369.2002
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