Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase

The ongoing selection of multidrug-resistant strains of Mycobacterium tuberculosis has markedly reduced the effectiveness of the standard treatment regimens. Thus, there is an urgent need for new drugs that are potent inhibitors of M. tuberculosis, that exhibit favorable resistance profiles, and tha...

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Bibliografiske detaljer
Main Authors: Gerum, A'Lissa B., Ulmer, Jonathan E., Jacobus, David P., Jensen, Norman P., Sherman, David R., Sibley, Carol Hopkins
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC128743/
https://ncbi.nlm.nih.gov/pubmed/12384337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3362-3369.2002
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