Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase

The ongoing selection of multidrug-resistant strains of Mycobacterium tuberculosis has markedly reduced the effectiveness of the standard treatment regimens. Thus, there is an urgent need for new drugs that are potent inhibitors of M. tuberculosis, that exhibit favorable resistance profiles, and tha...

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Detalhes bibliográficos
Main Authors: Gerum, A'Lissa B., Ulmer, Jonathan E., Jacobus, David P., Jensen, Norman P., Sherman, David R., Sibley, Carol Hopkins
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128743/
https://ncbi.nlm.nih.gov/pubmed/12384337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3362-3369.2002
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