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Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and cycloguanil have sparked renewed interest in the antimalarial drugs WR99210 and proguanil, the cycloguanil precursor. To investigate suggestions that WR...

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Sonraí Bibleagrafaíochta
Main Authors: Fidock, David A., Wellems, Thomas E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences of the USA 1997
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC23535/
https://ncbi.nlm.nih.gov/pubmed/9380737
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