Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase

The ongoing selection of multidrug-resistant strains of Mycobacterium tuberculosis has markedly reduced the effectiveness of the standard treatment regimens. Thus, there is an urgent need for new drugs that are potent inhibitors of M. tuberculosis, that exhibit favorable resistance profiles, and tha...

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發表在:	Antimicrob Agents Chemother
Principais autores:	Gerum, A'Lissa B., Ulmer, Jonathan E., Jacobus, David P., Jensen, Norman P., Sherman, David R., Sibley, Carol Hopkins
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2002
主題:	Mechanisms of Action: Physiological Effects
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.11.3362-3369.2002
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