Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase

The ongoing selection of multidrug-resistant strains of Mycobacterium tuberculosis has markedly reduced the effectiveness of the standard treatment regimens. Thus, there is an urgent need for new drugs that are potent inhibitors of M. tuberculosis, that exhibit favorable resistance profiles, and tha...

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Bibliographic Details
Main Authors: Gerum, A'Lissa B., Ulmer, Jonathan E., Jacobus, David P., Jensen, Norman P., Sherman, David R., Sibley, Carol Hopkins
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC128743/
https://ncbi.nlm.nih.gov/pubmed/12384337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3362-3369.2002
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