Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2000
Предметы:	Mechanisms of Action: Physiological Effects
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.14-18.2000
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