Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

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Detaylı Bibliyografya
Asıl Yazarlar: Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC89621/
https://ncbi.nlm.nih.gov/pubmed/10602716
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