Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 2000
Aiheet:	Mechanisms of Action: Physiological Effects
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.14-18.2000
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