Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

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I whakaputaina i:	Antimicrob Agents Chemother
Ngā kaituhi matua:	Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Microbiology (ASM) 2000
Ngā marau:	Mechanisms of Action: Physiological Effects
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.14-18.2000
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