Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Action: Physiological Effects
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.14-18.2000
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