Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

The naphthoquinone atovaquone is effective against Plasmodium and Pneumocystis carinii carinii. In Plasmodium, the primary mechanism of drug action is an irreversible binding to the mitochondrial cytochrome bc(1) complex as an analog of ubiquinone. Blockage of the electron transport chain ultimately...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Kaneshiro, Edna S., Sul, Donggeun, Hazra, Banasri
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2000
Onderwerpen:	Mechanisms of Action: Physiological Effects
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.14-18.2000
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