Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.

Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic acti...

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Detalhes bibliográficos
Main Authors: Ittarat, I, Asawamahasakda, W, Bartlett, M S, Smith, J W, Meshnick, S R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC162535/
https://ncbi.nlm.nih.gov/pubmed/7726490
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