Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.

Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic acti...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Ittarat, I, Asawamahasakda, W, Bartlett, M S, Smith, J W, Meshnick, S R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7726490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.2.325
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